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TisB-IstR toxin-antitoxin system
The TisB-IstR toxin-antitoxin system is the first known toxin-antitoxin system which is induced by the SOS response in response to DNA damage.
==IstR-1 and IstR-2==
IstR sRNA (inhibitor of SOS-induced toxicity by RNA) is a family of non-coding RNA first identified in ''Escherichia coli''. There are two small RNAs encoded by the IstR locus: IstR-1 and IstR-2, of which IstR-1 works as antitoxins against the toxic protein (TisB ) (toxicity-induced by SOS B) which is encoded by the neighbouring ''tisAB'' gene. IstR-1 is a 75 nucleotide transcript expressed constitutively throughout growth, whereas IstR-2 is a 140 nucleotide transcript induced by Mitomycin C (MMC). Both genes are thought to be regulated by LexA.〔
Deletion analysis confirmed the function of IstR, ''E. coli'' strain K-12 could not grow in the absence of IstR when ''tisAB'' was present. Inserting IstR genes on a plasmid allowed the bacteria to grow normally. Further studies showed that expression of IstR-1 alone is enough to remedy the toxic effects of TisB.〔 IstR-2 is not involved in the regulation of ''tisAB''.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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